https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45030 TAS2R4 (rs2233998 and rs2234001) and TAS2R5 (rs2227264) were associated with body mass index (BMI). Genotyping (Taqman qPCR assays) was performed on DNA extracted from blood samples (n = 563) from an elderly cohort. Homozygosity for the minor allele of all polymorphisms was significantly associated with a lower BMI in males. The TAS2R4-rs2233998 CC genotype, the TAS2R4-rs2234001 CC genotype and the TAS2R5-rs2227264 TT genotype were associated with lower BMI (2.1, 2.1 and 2.2 units; p = 0.002, 0.003 and 0.001, respectively). Epicatechin intake was not associated with BMI and genotype was not associated with epicatechin intake. This suggests that the association between TAS2R genotype and elevated BMI risk occurs through altered extra-oral responses and not directly via altered epicatechin intake.]]> Wed 26 Oct 2022 10:43:50 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:35659 Wed 24 Jun 2020 14:51:42 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:42962 Wed 22 Feb 2023 17:05:53 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:37585 Wed 19 Jan 2022 15:19:31 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:33649 Wed 19 Jan 2022 15:16:53 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:44188 Wed 19 Apr 2023 14:52:52 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30119 Wed 15 Dec 2021 16:11:02 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:38672 Wed 15 Dec 2021 14:39:24 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:43197 n = 649) Australian cross-sectional study population. Genetic analysis was used to score vitamin D- and folate-related gene polymorphisms (n = 22), along with two pigmentation gene variants (IRF4-rs12203592/HERC2-rs12913832). Red cell folate and vitamin D₃ were measured by immunoassay and HPLC, respectively. Results: i. Ultraviolet radiation (UVR) and pigmentation genes interact to modify blood vitamin levels; Light skin IRF4-TT genotype has greatest folate loss while light skin HERC2-GG genotype has greatest vitamin D₃ synthesis (reflected in both TOMS and seasonal data). ii. UV-wavelength exhibits a dose–response relationship in folate loss within light skin IRF4-TT genotype (305 > 310 > 324 > 380 nm). Significant vitamin D₃ photosynthesis only occurs within light skin HERC2-GG genotype, and is maximal at 305 nm. iii. Three dietary antioxidants (vitamins C, E, and β-carotene) interact with UVR and pigmentation genes preventing oxidative loss of labile reduced folate vitamers, with greatest benefit in light skin IRF4-TT subjects. The putative photosensitiser, riboflavin, did not sensitize red cell folate to UVR and actually afforded protection. iv. Four genes (5xSNPs) influenced blood vitamin levels when stratified by pigmentation genotype; MTHFR-rs1801133/rs1801131, TS-rs34489327, CYP24A-rs17216707, and VDR-ApaI-rs7975232. v. Lightest IRF4-TT/darkest HERC2-AA genotype combination (greatest folate loss/lowest vitamin D₃ synthesis) has 0% occurrence. The opposing, commonest (39%) compound genotype (darkest IRF4-CC/lightest HERC2-GG) permits least folate loss and greatest synthesis of vitamin D₃. Conclusion: New biophysical evidence supports the vitamin D-folate hypothesis for evolution of skin pigmentation.]]> Wed 14 Sep 2022 09:33:28 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52452 Wed 11 Oct 2023 15:01:49 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:14161 Wed 11 Apr 2018 16:03:17 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:14160 -/-), 4^-/- or 2/4^-/- BALB/c mice. Wt mice had moderate disease and infection. TLR2^-/- mice had more severe disease and more intense and prolonged infection compared to other groups. TLR4^-/- mice were asymptomatic. TLR2/4^-/- mice had severe early disease and persistent infection, which resolved thereafter consistent with the absence of symptoms in TLR4^-/- mice. Wt mice mounted robust innate and adaptive responses with an influx of natural killer (NK) cells, neutrophils, myeloid (mDCs) and plasmacytoid (pDCs) dendritic cells, and activated CD4⁺ and CD8⁺ T-cells into the lungs. Wt mice also had effective production of interferon (IFN)c in the lymph nodes and lung, and proliferation of lymph node T-cells. TLR2^-/- mice had more intense and persistent innate (particularly neutrophil) and adaptive cell responses and IL-17 expression in the lung, however IFNγ responses and T-cell proliferation were reduced. TLR2/4^-/- mice had reduced innate and adaptive responses. Most importantly, neutrophil phagocytosis was impaired in the absence of TLR2. Thus, TLR2 expression, particularly on neutrophils, is required for effective control of Chlamydia respiratory infection in early life. Loss of control of infection leads to enhanced but ineffective TLR4-mediated inflammatory responses that prolong disease symptoms. This indicates that TLR2 agonists may be beneficial in the treatment of early life Chlamydia infections and associated diseases.]]> Wed 11 Apr 2018 13:47:06 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:9558 Wed 11 Apr 2018 12:40:26 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:19565 Wed 11 Apr 2018 10:55:18 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:14158 Wed 11 Apr 2018 10:28:43 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:10519 Wed 11 Apr 2018 09:13:51 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:49870 Wed 07 Jun 2023 15:47:31 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30422 Wed 04 Sep 2019 10:04:44 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:37683 n = 536) was conducted to explore relationships between the salt taste-related SNP TRPV1-rs8065080 (assessed by Taqman genotyping assay), dietary habits and biomarkers of health. Data were analysed with standard least squares regression modelling and Tukey's HSD post hoc tests. No association was found between the TRPV1-rs8065080 genotype, sodium intake or multiple diet quality indices (assessed by food frequency questionnaire). Sodium-related markers of health including blood pressure and markers of kidney function (urinary creatinine and albumin/creatinine ratio) and general health markers, such as Body Mass Index (BMI), were also not related to TRPV1-rs8065080 genotype. To date, this study is the most comprehensive investigation conducted to determine if the TRPV1-rs8065080 genotype relates to sodium intake and health markers influenced by sodium intake. Although no significant relationships were found, these findings are an important contribution to the limited body of knowledge surround this SNP. In addition to further research across other ages and cultures, the TRPV1-rs8065080 genotype may interact with other ion channels, and so further studies are required to determine if polymorphic variations influence sodium intake, diet and health.]]> Wed 02 Mar 2022 14:24:15 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:49012 Wed 01 May 2024 15:54:23 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45945 Tue 15 Nov 2022 14:54:52 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:55633 Tue 11 Jun 2024 18:44:40 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45553 Tue 01 Nov 2022 11:03:26 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45394 Thu 27 Oct 2022 16:40:08 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45310 Thu 27 Oct 2022 13:56:22 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:42951 KCNJ2 gene involved in the transduction of sour taste have been linked to variations in sour taste and non-gustatory functions. However, relationships between sour taste genetics, mild cognitive impairment, and diet quality are yet to be elucidated. This study investigated the associations between the presence of the KCNJ2-rs236514 variant (A) allele, diet quality indices, and mild cognitive impairment evaluated by the Mini-Mental State Examination (MMSE), in a secondary cross-sectional analysis of data from the Retirement Health & Lifestyle Study. Data from 524 elderly Australians (≥65y) were analyzed, using standard least squares regression and nominal logistic regression modeling, with demographic adjustments applied. Results showed that the presence of the KCNJ2-A allele is associated with increased proportions of participants scoring in the range indicative of mild or more severe cognitive impairment (MMSE score of ≤26) in the total cohort, and males. These associations remained statistically significant after adjusting for age, sex, and diet quality indices. The absence of association between the KCNJ2-A allele and cognitive impairment in women may be related to their higher diet quality scores in all indices. The potential link between sour taste genotype and cognitive impairment scores may be due to both oral and extra-oral functions of sour taste receptors. Further studies are required on the role and relationship of neurotransmitters, sour taste genotypes and sour taste receptors in the brain, and dietary implications, to identify potential risk groups or avenues for therapeutic or prophylactic interventions.]]> Thu 08 Sep 2022 14:04:41 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:49088 Thu 04 May 2023 13:43:05 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:29938 Thu 03 Feb 2022 12:18:20 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:18898 Sat 24 Mar 2018 08:03:05 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:20869 Sat 24 Mar 2018 07:57:58 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:17909 Sat 24 Mar 2018 07:56:41 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:22009 Chlamydia and Haemophilus lung infection-induced SSIAAD. We used these models to investigate the effects of clarithromycin and amoxicillin treatment on immune responses and airways hyper-responsiveness (AHR) in Ova-induced, T helper lymphocyte (Th) 2 -associated steroid-sensitive AAD and infection-induced Th1/Th17-associated SSIAAD compared with dexamethasone treatment. Results: Clarithromycin and amoxicillin had similar antimicrobial effects on infection. Amoxicillin did attenuate some features, but did not broadly suppress either form of AAD. It did restore steroid sensitivity in SSIAAD by reducing infection. In contrast, clarithromycin alone widely suppressed inflammation and AHR in both steroid-sensitive AAD and SSIAAD. This occurred through reductions in Th2 responses that drive steroid-sensitive eosinophilic AAD and tumour necrosis factor a and interleukin 17 responses that induce SSIAAD. Conclusions: Macrolides have broad anti-inflammatory effects in AAD that are likely independent of their antimicrobial effects. The specific responses that are suppressed are dependent upon the responses that dominate during AAD.]]> Sat 24 Mar 2018 07:15:55 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:21996 Sat 24 Mar 2018 07:14:33 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:46833 Mon 29 Jan 2024 18:41:10 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:41872 Mon 15 Aug 2022 10:03:25 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:40176 Fri 22 Jul 2022 13:54:23 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:53849 Fri 19 Jan 2024 10:25:16 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:53847 Fri 19 Jan 2024 10:18:49 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:37039 Fri 07 Aug 2020 12:28:15 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:38444 Fri 05 Nov 2021 14:28:07 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:41525 Fri 05 Aug 2022 12:38:22 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:37726 Fri 03 Dec 2021 10:33:48 AEDT ]]>